The role of ifosfamide and cyclophosphamide in the multi-modality treatment after surgery for cure for small-cell bronchial carcinomas (SCLC)
Identifieur interne : 002634 ( Main/Exploration ); précédent : 002633; suivant : 002635The role of ifosfamide and cyclophosphamide in the multi-modality treatment after surgery for cure for small-cell bronchial carcinomas (SCLC)
Auteurs : K. Karrer [Autriche] ; H. Denck [Autriche] ; H. Karnicka-Mlodkowska [Pologne] ; P. Drings [Allemagne] ; J. Orel [Slovénie] ; M. Salzer [Autriche] ; M. Thermann [Allemagne] ; A. Lattuneddu [Italie] ; Y. Sun [République populaire de Chine] ; E. Hata [Japon] ; B. Berkarda [Turquie] ; L. Liao [République populaire de Chine] ; F. Bruno [Argentine] ; J. Rothmund [Autriche] ; H. Osada [Japon]Source :
- Medical Oncology and Tumor Pharmacotherapy [ 0736-0118 ] ; 1989-06-01.
Abstract
Abstract: For the optimisation of the therapy for small cell bronchial carcinomas (SCLC), surgery is used to eliminate the primary tumor and its regional lymph nodes and chemo- and radiotherapy for the general treatment of micrometastasis. After patho-histological examination of the operation specimen, randomization for two arms is performed for a standard chemotherapy (CAV) or a sequential chemotherapy using three different drug combinations. Thereafter all disease-free patients receive prophylactic cranial irradiation (PCI). Preliminary evaluations in December 1987, of 112 patients from 19 cooperating departments show that the survival rate projected for 2 yr of 43 patients at stage pT1–3 N0 M0 is 76%, of 43 patients at stage pT1–3 N1 M0 it is 63% and of 26 patients at stage pT1–3 N2 M0 it is 38%.
Url:
DOI: 10.1007/BF02985237
Affiliations:
- Allemagne, Argentine, Autriche, Italie, Japon, Pologne, République populaire de Chine, Slovénie, Turquie
- Bade-Wurtemberg, District de Karlsruhe, Vienne (Autriche)
- Heidelberg, Pékin, Tokyo, Vienne (Autriche)
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001387
- to stream Istex, to step Curation: 001387
- to stream Istex, to step Checkpoint: 001277
- to stream Main, to step Merge: 002707
- to stream Main, to step Curation: 002634
Le document en format XML
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<author><name sortKey="Karnicka Mlodkowska, H" sort="Karnicka Mlodkowska, H" uniqKey="Karnicka Mlodkowska H" first="H." last="Karnicka-Mlodkowska">H. Karnicka-Mlodkowska</name>
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<front><div type="abstract" xml:lang="en">Abstract: For the optimisation of the therapy for small cell bronchial carcinomas (SCLC), surgery is used to eliminate the primary tumor and its regional lymph nodes and chemo- and radiotherapy for the general treatment of micrometastasis. After patho-histological examination of the operation specimen, randomization for two arms is performed for a standard chemotherapy (CAV) or a sequential chemotherapy using three different drug combinations. Thereafter all disease-free patients receive prophylactic cranial irradiation (PCI). Preliminary evaluations in December 1987, of 112 patients from 19 cooperating departments show that the survival rate projected for 2 yr of 43 patients at stage pT1–3 N0 M0 is 76%, of 43 patients at stage pT1–3 N1 M0 it is 63% and of 26 patients at stage pT1–3 N2 M0 it is 38%.</div>
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